{"id":8592,"date":"2023-05-11T04:54:42","date_gmt":"2023-05-11T04:54:42","guid":{"rendered":"https:\/\/tmckolkata.com\/in\/donor-appointment-and-faqs-copy\/"},"modified":"2023-05-29T09:20:07","modified_gmt":"2023-05-29T09:20:07","slug":"products_service_transfusion_med","status":"publish","type":"page","link":"https:\/\/tmckolkata.com\/in\/products_service_transfusion_med\/","title":{"rendered":"Products and services &#8211; Transfusion Medicine"},"content":{"rendered":"<div id='av-layout-grid-1'  class='av-layout-grid-container av-2ymm6y-4807741fc6365891d0b9190d6c51310e entry-content-wrapper main_color av-flex-cells  avia-builder-el-0  el_before_av_layout_row  avia-builder-el-first   container_wrap sidebar_right'  >\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" 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class='flex_cell av-lhhdg5z8-25092833b8cdcaf731f5247599546442 av-gridrow-cell av_one_fourth no_margin  avia-builder-el-4  el_after_av_cell_one_fourth  el_before_av_cell_one_fourth  content-align-middle'  ><div class='flex_cell_inner'><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lhhdgolw-baa949d6d8942bbf7afaa4b585789639\">\n.flex_cell.av-lhhdgolw-baa949d6d8942bbf7afaa4b585789639{\nvertical-align:middle;\nbackground-color:#5fb4e4;\n}\n.responsive #top #wrap_all .flex_cell.av-lhhdgolw-baa949d6d8942bbf7afaa4b585789639{\npadding:15px 15px 15px 15px !important;\n}\n<\/style>\n<div class='flex_cell av-lhhdgolw-baa949d6d8942bbf7afaa4b585789639 av-gridrow-cell av_one_fourth no_margin  avia-builder-el-5  el_after_av_cell_one_fourth  el_before_av_cell_one_fourth  content-align-middle'  ><div class='flex_cell_inner'><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lhhdh844-cd790256d030facbd84bf50cf5002708\">\n.flex_cell.av-lhhdh844-cd790256d030facbd84bf50cf5002708{\nvertical-align:middle;\nbackground-color:#80c7ef;\n}\n.responsive #top #wrap_all .flex_cell.av-lhhdh844-cd790256d030facbd84bf50cf5002708{\npadding:15px 15px 15px 15px !important;\n}\n<\/style>\n<div class='flex_cell av-lhhdh844-cd790256d030facbd84bf50cf5002708 av-gridrow-cell av_one_fourth no_margin  avia-builder-el-6  el_after_av_cell_one_fourth  avia-builder-el-last  content-align-middle'  ><div class='flex_cell_inner'><\/div><\/div>\n<\/div><div id='after_grid_row_2'  class='main_color av_default_container_wrap container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-8592'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-klutz8ls-5b2738d67747f3482a279b2b4c1d470e\">\n#top .av-special-heading.av-klutz8ls-5b2738d67747f3482a279b2b4c1d470e{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-klutz8ls-5b2738d67747f3482a279b2b4c1d470e .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-klutz8ls-5b2738d67747f3482a279b2b4c1d470e .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-klutz8ls-5b2738d67747f3482a279b2b4c1d470e av-special-heading-h3 blockquote elegant-quote elegant-centered  avia-builder-el-7  el_after_av_layout_row  el_before_av_hr  avia-builder-el-first '><h3 class='av-special-heading-tag '  itemprop=\"headline\"  ><span class=\"heading-wrap\">Products and services<\/span><\/h3><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lhio9cur-d4610d6b3b7888586bb02876da7b80b4\">\n#top .hr.hr-invisible.av-lhio9cur-d4610d6b3b7888586bb02876da7b80b4{\nheight:20px;\n}\n<\/style>\n<div  class='hr av-lhio9cur-d4610d6b3b7888586bb02876da7b80b4 hr-invisible  avia-builder-el-8  el_after_av_heading  el_before_av_three_fifth '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<div  class='flex_column av-3x4op6-a472816fee720a7456c414935603ac9b av_three_fifth  avia-builder-el-9  el_after_av_hr  el_before_av_two_fifth  first flex_column_div  '     ><section  class='av_textblock_section av-kl96eiv0-6d2d3b8215213988d4e00e381e2ddbbd '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><h5><strong>Diagnostic services:<\/strong><\/h5>\n<p><strong>ABO and Rh grouping <\/strong><\/p>\n<p style=\"text-align: justify;\">This test is for ABO and RhD determination of an individual. This is based on the principle of antigen antibody reaction.<\/p>\n<p><strong>Subgroup study<\/strong><\/p>\n<p style=\"text-align: justify;\">Some individuals have less ABO antigens on red cells that cannot be detected in usual blood grouping methods. For detecting these groups, medically terminated as \u2018subgroups\u2019; some specialized techniques (adsorption-elution technique, saliva study, etc.) are used.<\/p>\n<p><strong>Red cell antibody screening (ICT or IAT)<\/strong><\/p>\n<p style=\"text-align: justify;\">This is a test performed to detect presence of any free antibody in the serum\/plasma of a patient which might cause destruction of red cells (hemolysis) inside body.<\/p>\n<p><strong>Panel for red cell antibody identification<\/strong><\/p>\n<p style=\"text-align: justify;\">This test helps to identify the specific antibody causing the hemolysis. It is done when the antibody screening test is positive.<\/p>\n<\/div><\/section><\/div>\n<div  class='flex_column av-2behvu-0964bfbc4ed132bce10c6272cd02cb18 av_two_fifth  avia-builder-el-11  el_after_av_three_fifth  el_before_av_textblock  flex_column_div  '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lhio75sp-ed84bfc799d149957ccee7a4660a7286\">\n.av_promobox.av-lhio75sp-ed84bfc799d149957ccee7a4660a7286{\ncolor:#ffffff;\nbackground-color:#444444;\nborder-style:groove;\nborder-radius:5px 5px 5px 5px;\nbox-shadow: 5px 5px 5px 2px #c1c1c1;\n}\n<\/style>\n<div  class='av_promobox av-lhio75sp-ed84bfc799d149957ccee7a4660a7286 avia-button-no  avia-builder-el-12  avia-builder-el-no-sibling '><div class='avia-promocontent'><p>\n<strong>Our inventory of standard blood products and components includes:<\/strong><\/p>\n<ol>\n<li>Packed RBCs<\/li>\n<li>FFP<\/li>\n<li>Cryoprecipitate<\/li>\n<li>Random donor platelets<\/li>\n<li>Single donor apheresis platelets<\/li>\n<li>Single donor apheresis granulocytes<\/li>\n<li>Buffy coat derived granulocytes<\/li>\n<li>Cryo-poor plasma<\/li>\n<li>Washed red cells concentrates<\/li>\n<li>Irradiated blood components<\/li>\n<li>Autologous blood products<\/li>\n<\/ol>\n<p><strong>\u00a0<\/strong><\/p>\n<\/div><\/div><\/div>\n<section  class='av_textblock_section av-lhiod5zb-d099e778a3eafad21e6f534463dc52b0 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><strong>Antibody titration <\/strong><\/p>\n<p style=\"text-align: justify;\">This test is done to predict the amount\/concentration of an antibody present in plasma of an individual. Titrations are performed by conventional tube technique at saline phase and AHG phase (after DTT treatment) for IgM and IgG, respectively.<\/p>\n<p><strong>Full red cell antigen typing<\/strong><\/p>\n<p style=\"text-align: justify;\">There are antigens that are called minor blood group antigens such as extended Rh (C, c, D, E, e); Kell (K); Duffy (Fy<sup>a<\/sup>, Fy<sup>b<\/sup>); Kidd (Jk<sup>a<\/sup>, Jk<sup>b<\/sup>); MNS (M, N, S, s); etc. Full antigen typing is done to detect these minor blood group antigens.<\/p>\n<p><strong>\u00a0<\/strong><strong>DCT or DAT <\/strong><\/p>\n<p style=\"text-align: justify;\">When a patient develops antibody to a red cell antigen, the antibodies first coat the red cells. This coating of red cells can be tested by the direct antiglobulin test (DAT) which is also known as direct coombs test (DCT). This test is indicated to diagnose autoimmune hemolytic anemia (AIHA), delayed hemolytic transfusion reaction (DHTR), hemolytic disease of fetus and newborn (HDFN) etc.<\/p>\n<p><strong>\u00a0<\/strong><strong>AIHA panel<\/strong><\/p>\n<p style=\"text-align: justify;\">Once DAT is positive in a suspected patient with an immune-hemolysis, further evaluation in a stepwise approach is performed to identify laboratory and clinical evidence of hemolysis and then the immune nature of hemolysis is determined by battery of tests that includes sub-classification of DAT, DAT dilution, adsorption, acid elution etc. These are all included in the AIHA panel.<\/p>\n<p><strong>Cold antibody titration<\/strong><\/p>\n<p style=\"text-align: justify;\">Some antibodies cause destruction of RBCs at cold temperature. These are called cold antibodies. When present in high titers these can lead to Cold agglutinin disease. This test is performed to estimate the concentration of such cold antibodies along with the thermal range and their specificity.<\/p>\n<p><strong>Pre BMT cross-match<\/strong><\/p>\n<p style=\"text-align: justify;\">Patients with different hematological diseases may undergo allogeneic bone marrow transplantation (BMT) with a related or unrelated HLA matched donor. In pre-BMT cross-match, the patient and the donor\u2019s blood group, extended red cell phenotyping, DAT, antibody screening and compatibility were checked.<\/p>\n<p><strong>Patients on Daratumumab <\/strong><\/p>\n<p style=\"text-align: justify;\">Di-thio-threitol (DTT) treated red cells are used for pre-transfusion testing or red cell genotyping is performed in these patients to predict the red cell phenotype.<\/p>\n<p><strong>\u00a0<\/strong><strong>Platelet antibody screening and cross-match<\/strong><\/p>\n<p style=\"text-align: justify;\">Transfusion dependent patients with underlying hematological diseases; may develop antibody against platelet antigens (HLA or HPA). In platelet antibody screening using the solid phase assay patients can be screened for these antibodies. Once the screening becomes positive, platelet cross-matching is performed for necessary platelet transfusions in these patients.<\/p>\n<\/div><\/section>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lhk3v6gf-ec37f0f98da96d5790336dcf88ddda2a\">\n.av-horizontal-gallery.av-lhk3v6gf-ec37f0f98da96d5790336dcf88ddda2a .av-horizontal-gallery-inner{\npadding-bottom:25%;\n}\n<\/style>\n<div  class='av-horizontal-gallery av-lhk3v6gf-ec37f0f98da96d5790336dcf88ddda2a av-horizontal-gallery-large-gap av-horizontal-gallery--effect  avia-builder-el-14  el_after_av_textblock  el_before_av_hr  av-slideshow-ui av-control-default av-slideshow-manual av-loop-once av-loop-manual-once av-horizontal-gallery-1' 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